{
  "node_id": "ich-e9-r1-estimands-sensitivity-analysis-pharma-2019",
  "title": "ICH E9(R1) - Addendum on Estimands and Sensitivity Analysis in Clinical Trials: Estimand Framework, Intercurrent Events and Missing Data Strategies",
  "domain": "Pharmaceuticals & Life Sciences",
  "version": "1.0.1",
  "last_updated": "2026-04-30",
  "bluf": "This regulation requires sponsors of clinical trials to identify and justify the estimand of interest, as stated…",
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  "primary_citations_count": 9,
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  "citation_preview": [
    "ICH E9(R1), Section 1.1 - Introduction",
    "ICH E9(R1), Section 2.1 - Study Design"
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}