{
  "node_id": "us-45-cfr-46-116-common-rule-informed-consent",
  "title": "US 45 CFR 46.116 (Common Rule): General Requirements for Informed Consent",
  "domain": "Education & Research",
  "version": "1.0.0",
  "last_updated": "2026-06-28",
  "bluf": "Section 46.116 of the Common Rule sets the general requirements for informed consent in federally conducted or supported human-subjects research…",
  "paywall": {
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    "skyfire_id": "41779894-ece2-4163-9761-b3b1b76e19b0"
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  "crosswalks": {
    "_available_keys": [
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    "_note": "Full crosswalk values included in vault response"
  },
  "dependencies": [
    "us-45-cfr-part-46-common-rule-human-subjects-research",
    "us-national-research-act-1974-irb-belmont",
    "us-21-cfr-part-50-protection-human-subjects"
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  "primary_citations_count": 8,
  "workflow_steps_count": 10,
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  "citation_preview": [
    "US 45 CFR 46.116: General requirements for informed consent",
    "46.116(a)(1): Before involving a human subject in research covered by this policy, an investigator shall obtain the legally effective informed consent of the subject or the subject's legally authorized representative"
  ]
}