What ISSCR Guidelines for Stem Cell Research and Clinical Translation (2021) requires
The International Society for Stem Cell Research (ISSCR) 2021 Guidelines for Stem Cell Research and Clinical Translation represent the international consensus framework governing embryonic stem cell research, human embryo culture, stem cell-based embryo models (SCBEMs), chimeric animal research, heritable human genome editing (prohibited), and clinical translation of cell-based therapies; the 2021 revision restructures the oversight framework into three tiers (Prohibited, Requires Specialized Oversight, Permitted with Appropriate Oversight) and removes the former absolute 14-day rule on human embryo culture in favour of a case-by-case scientific and ethics review process.
Pillar: Biotech & Genomics · Authority: International Society for Stem Cell Research (ISSCR) - Guidelines Task Force; endorsed by ISSCR Board of Directors · Version: 2021 · Last updated:
Primary source: https://www.isscr.org/guidelines
SHA-256 integrity: 7bd8f85ac04689327cff0c6c44a4398cfe2279621708fe6300794f03ae4f49dc
Primary Citations — 5 traced to source
- {"title":"ISSCR Guidelines for Stem Cell Research and Clinical Translation (2021)","url":"https://www.isscr.org/guidelines","section":"Section 2 (Human Embryo Research - 14-day rule revision, SCBEM governance), Section 3 (Chimeric Animals, Heritable Genome Editing prohibition), Section 4 (Clinical Translation pathway), Section 5 (Ethics and Oversight)"}
- {"title":"ISSCR 2021 Guidelines - Cell Stem Cell Companion Article (Lovell-Badge et al.)","url":"https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(21)00198-7","section":"Three-tier oversight framework rationale; discussion of 14-day rule revision; SCBEM classification justification"}
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